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   HOME > Faculty & Staff > Faculty > Orwin

Liz Orwin

Elizabeth J. Orwin
Assistant Professor of Engineering and Biology

Education & Professional Experience

  • B.S., Harvey Mudd College
  • M.S., Ph.D., University of Minnesota
  • Postdoctoral Research Associate, University of Minnesota
  • Technical Biological Engineer, Gel-Del Technologies, St. Paul, MN

Teaching

  • Bio 52: Introduction to Biology
  • Bio 190/Engr 190b: Biomechanics
  • Engr 4: Introduction to Engineering Design
  • Engr 8: Design Representation and Realization
  • Engr 59: Introduction to Systems Engineering
  • Engr 80: Experimental Engineering Lab
  • Engr 101: Advanced Systems Engineering
  • Engr 164/Biol 164: Introduction to Biomedical Engineering
  • Chem 25I: Freshman Interdisciplinary Laboratory

Research Interests

Professor Orwin’s laboratory is involved in the design of a tissue-engineered artificial corneal model. We are creating a culture system for our tissues that can simulate physiological conditions and allow us to study the cellular and matrix factors which contribute to tissue transparency. This project is multi-faceted; we are using a variety of techniques in a multidisciplinary approach to this complicated problem. For more details, please see our website.

Publications & Presentations

Journal Articles

Orwin, E. J., M. L. Borene, and A. Hubel. 2003. Biomechanical and optical characteristics of a corneal stromal equivalent. J. Biomech. Eng. 125(4): 439-444. [abstract | article (pdf)]

Orwin, E. J., and A. Hubel. 2000. In vitro culture characteristics of corneal epithelial, endothelial, and keratocyte cells in a native collagen matrix. Tissue Eng. 6(4): 307-319. [abstract | article (pdf)]

Published Conference Papers

Raub*, C. B., E. J. Orwin, and R. Haskell. 2004. Immunogold labeling to enhance contrast in optical coherence microscopy of tissue engineered corneal constructs. Proc. IEEE Eng. Med. Biol. Soc. Conf. 2004 1: 1210-1213. [abstract]

Orwin, E. J., S. Lee*, C. Raub*, T. Icenogle*, M. Arman*, A. Cho*, R. Lovec*, A. Malone*, R. C. Haskell, B. M. Hoeling, and D. C. Petersen. 2004. Optical coherence microscopy for the evaluation of a tissue-engineered artificial cornea. Proc. IEEE Eng. Med. Biol. Soc. Conf. 2004 2: 1218-1221. [abstract]

Hubel, A. and E. J. Orwin. 2001. Migration of corneal epithelium on a collagen sponge in vitro and in vivo. Trans. Am. Soc. Mech. Eng. BED-vol50: p351-352. [article (pdf)]

Presentations

Tan*, A., S. Rodenburg*, A. Voorhees*, M. K. Bechtel, and E. J. Orwin. “The Effect of Modified Media on the Expression of ALDH3A1 and α-SMA in Human Corneal Stromal Cells.” American Society for Cell Biology Annual Meeting, Dec. 2005.

Wray*, L., B. Smith*, M. Little, A. Voorhees*, A. Shah*, and E. Orwin. “Designing a Tissue-Engineered Corneal Model.” Los Angeles Tissue Engineering Meeting, Los Angeles, CA; Dec. 3, 2005.

Shoffeitt*, J., M. Arman*, C. Chan*, A. Voorhees*, S. Rodenburg*, A. Tan*, R. Haskell, D. Petersen, M. Bechtel, and E. Orwin. “Monitoring the Phenotype of Corneal Keratocytes in a Tissue Engineered Corneal Model.” Los Angeles Tissue Engineering Meeting, Los Angeles, CA; Dec. 3, 2005

Arman*, M., J. Shoffeitt*, R. Haskell, E. Orwin, and D. Petersen. “Investigating the Viability of Immunogold Labeling for Determining Corneal Cell Phenotype with the Optical Coherence Microscope (OCM).” CA Tissue Engineering 4th Annual Meeting, UC Irvine, CA, Oct 2005.

Little, M., B. Smith*, L. Wray*, and E. Orwin. “Approximating the Extracellular Matrix of the Cornea by Electrospinning Gelatin Fibers.” CA Tissue Engineering 4th Annual Meeting, UC Irvine, CA, Oct 2005.

Tan*, A., S. Rodenburg*, A. Voorhees*, M. K. Bechtel, and E. J. Orwin. “The Effect of TGF-β and Serum on the expression of ALDH3A1, TKT and α-SMA in Human Corneal Stromal Cells.” Western Eye Research Conference, Laguna Beach, CA; Sept. 25-28, 2005.

E. Orwin. “A Model for Tissue-Engineered Corneal Matrices.” Western Eye Research Conference, Laguna Beach, CA; Sept. 25-28, 2005.

Shah*, A., A. Voorhees*, V. Ravi, and E. Orwin. “Cytotoxicity of Several Materials for Potential Use in a Corneal Tissue Bioreactor.” UCLA BMES Symposium, Jan 2005.

Shah, A.*, A. Voorhees*, and E. Orwin. “The Design, Fabrication, and Characterization of a Bioreactor System to Study the Effects of Intraocular Pressure (IOP) on Corneal Replacement Tissue Growth.” CA Tissue Engineering 3rd Annual Meeting, Stanford, CA, Oct 2004.

Raub, C.*, M. Lee*, T. Icenogle*, R. Lovec*, M. Arman*, A. Cho*, D. Petersen, R. Haskell, and E. Orwin. “Optical Coherence Microscopy for the Evaluation of the Transparency of a Tissue-Engineered Cornea.” Biomedical Engineering Society Annual Meeting. Oct 1-4, 2003.

Crofut, A. M.*, and E. J. Orwin. “The Impact of Dynamic Loading in Tissue Engineering of Meniscal Cartilage.” SCCUR, California Institute of Technology, Nov. 2002.

Icenogle, T.*, M. Lee*, C. Raub*, and E. J. Orwin. “Effects of Glutaraldehyde Crosslinking on Corneal Fibroblast-Seeded Collagen Sponges.” CA Tissue Eng Meeting, UCLA, Sept. 2002.

Orwin, E. J., and R. J. Bennett. 2002. “Trials and tribulations of a freshman design course.” ASEE annual conference, Montreal, Quebec, June 2002.

Orwin, E. J., and A. Hubel. “Corneal Wound Healing: Role of Matrix Composition in Transparency.” The Association for Research in Vision and Ophthalmology Annual Meeting, May 9-14, 1999.

Orwin, E. J., and A. Hubel. 1999. “Corneal wound healing: role of matrix composition in transparency.” The Association for Research in Vision and Ophthalmology Annual Meeting, May 9-14, 1999.

Cornelius, E. J., and A. Hubel. 1998. “Development of a tissue engineered artificial corneal replacement.” The Association for Research in Vision and Ophthalmology Annual Meeting. May 10-15, 1998.

Cornelius, E., and A. Hubel. 1997. “Development of a tissue engineered corneal replacement.” Ann. Biomed. Eng. 25 (S1): S-58, 1997.

*HMC student

 


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